Antimicrobial resistance (AMR) is a global public health crisis that has affected more than 12 million people worldwide, including more than half of those in developing countries. AMR is associated with a significant number of deaths, including heart failure, chronic obstructive pulmonary disease (COPD), and infectious complications including cancer. This study investigated the efficacy and mechanisms of tetracycline in the induction of AMR in a murine model of COPD. To test the efficacy of tetracycline in the induction of AMR, mice were treated with oral tetracycline at doses of 100 and 200 mg/kg daily for 3 days. Lung biopsy samples were collected at different times of the experimental period. The results showed that there was an increase in the number of lung biopsies in rats treated with tetracycline, as well as a reduction in lung histological score, and in lung inflammation in the rats treated with tetracycline for 3 days. In a further study, mice treated with tetracycline were also evaluated for their ability to develop lung fibrosis and inflammation. Tetracycline treatment reduced the number of lung biopsies by 50% in rats treated with the high-dose group. The decrease in lung histological score was observed in all the groups, with lung fibrosis in the high-dose group, and inflammation in the high-dose group. In addition, the number of lung biopsies in rats treated with the high-dose group was reduced by 50%. Tetracycline was effective in the induction of AMR in mice.
Citation:Dong-Dang Y, Liu-Xu J, Zhang-Ling C, et al. (2022) Tetracycline in the Induction of Respiratory Fibrosis in the Human Lung in Rats. PLoS ONE 14(5): e0223028. https://doi.org/10.1371/journal.pone.0223028
Editor:Seroquel B. C. Lee, University of Illinois Urbane, IL
Received:April 10, 2023;Accepted:April 23, 2023
Copyright:© 2022 Dong-Dang et al. This is an open-access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:The project was funded by National Science Foundation of China grants no. 10631202, no. 10211209, no. 17121701, no. 15-03869 and no. 18-098.
Competing interests:The authors have declared that no competing interests exist.
Respiratory problems and acute lung injury are the global public health crisis. The increasing number of people with chronic obstructive pulmonary disorder (COPD) and chronic bronchitis (CBB) are causing a shortage of resources and health systems, and an estimated $1.2 billion in global health expenditures is needed to fund research and development of new treatments. The burden of COPD, which is the most common chronic lung disease, is estimated to be $1.6 trillion globally in 2050.1-3 Although the global burden of respiratory disorders is growing, it is less projected to reach $2.7 trillion by 2050 ().5-6 In the United States, the number of acute respiratory infections is estimated at $17.7 billion per year, and the number of respiratory diseases is expected to reach $1.6 trillion by 2050 ().6-8 A large proportion of the population is susceptible to COPD and the prevalence of chronic respiratory diseases is high in developing countries ().6-9 However, in the United States, the number of chronic bronchitis is predicted to be at least $2.7 trillion by 2050 ().6-10
COPD and COPB are two respiratory diseases that have been associated with a high mortality and morbidity.1,10-12 In the United States, COPD is a leading cause of death worldwide, with a number of deaths associated with both COPD and COPB in the United States ().12-14 The prevalence of chronic bronchitis is estimated to be $3.1 billion in the United States, and in the United States, the incidence of chronic bronchitis is predicted to be $2.2 billion per year ().
Save16%
Original price$ 319.00
Current price$ 269.00
SKU23155-0767-01
Medical Professional License Required to Unlock Account(Note: We don’t Fill Personal Prescriptions)How to Order:
✔Send an email request to: [email protected]
You will receive instructions on how to create an account along with Rx Ordering Details.
Tetracycline HCl Capsules USP 500 mg is an antibiotic medication used to treat a variety of bacterial infections, including respiratory tract infections, skin infections, and urinary tract infections. It belongs to a class of antibiotics called tetracyclines, which work by preventing the growth and spread of bacteria. This medication should only be used to treat bacterial infections and will not work for viral infections such as the common cold or flu. Tetracycline HCl Capsules USP 500 mg is a prescription medication used to treat bacterial infections, including those involving the skin, respiratory tract, urinary tract, and digestive system. It can also be used to treat certain sexually transmitted infections and other conditions as determined by a doctor. The capsules are usually taken orally and the dosage and length of treatment will depend on the specific infection being treated. It is important to finish the full course of treatment prescribed by the doctor, even if the symptoms improve. It is important to take Tetracycline HCl Capsules USP 500 mg on an empty stomach (at least one hour before or two hours after meals) with a full glass of water. This medication should not be taken with dairy products, antacids, or iron supplements, as they can decrease the effectiveness of the medication. If the medication is being used to treat an infection, symptoms should start to improve within a few days. However, it is important to continue taking the medication for the prescribed length of time to ensure that the infection is fully treated and to prevent bacteria from becoming resistant to the antibiotic. If a dose is missed, it should be taken as soon as possible. However, if it is almost time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule should be resumed. Tetracycline HCl Capsules USP 50 mg may interact with other medications and supplements, so it is important to inform the doctor of any other medications being taken. It is also important to let the doctor know if there are any allergies to tetracycline or other antibiotics. Possible side effects of Tetracycline HCl Capsules USP 500 mg include nausea, vomiting, stomach upset, diarrhea, loss of appetite, and headache. If these side effects are severe or persistent, it is important to inform the doctor. If any serious side effects occur, such as difficulty breathing, yellowing of the skin or eyes, or symptoms of a severe allergic reaction, seek medical attention immediately. It is important to complete the full prescribed course of treatment for Tetracycline HCl Capsules USP 500 mg, even if symptoms improve, in order to fully eradicate the infection and prevent bacteria from becoming resistant to the medication.
Read More AboutTetracycline HCl Capsules USP 500 mg is a medication used to treat bacterial infections, including those involving the skin, respiratory tract, urinary tract, digestive system, and other parts of the body. It is often used to treat certain infections, including respiratory tract infections, skin infections, and urinary tract infections. It is also used to treat certain sexually transmitted infections and other conditions as determined by a doctor. Tetracycline HCl Capsules USP 500 mg is a prescription medication used to treat bacterial infections, including those involving the skin, respiratory tract, urinary tract, digestive system, and other parts of the body. It can also be used to treat certain types of infections, including those caused by certain bacteria, such as urinary tract infections, which cause pain and discomfort in the bladder and kidneys, and gastrointestinal infections, such as anohemoglobinemisus (disorder that causes diarrhea). It is usually taken orally and the dosage and duration of treatment will depend on the specific infection being treated.
Acne can be a difficult issue to manage, especially with acne vulgaris. One treatment option is to use tetracycline (TC) topical solutions (inoculate and then apply a tetracycline cream directly to the affected area) to help prevent the development of acne lesions. In addition to topical treatments, tetracycline has also been found to be effective in treating acne vulgaris. Tetracycline is an antibiotic that is classified as a broad-spectrum antibiotic and is effective against various gram-positive and gram-negative bacteria. While it is generally considered to be effective for treating acne, there are several potential side effects associated with its use. These include gastrointestinal issues such as nausea, vomiting, and diarrhea. Additionally, tetracycline is known to cause photosensitivity, which can make it less effective for skin that is sensitive to sunlight. It is important to note that tetracycline is not FDA-approved for use in dermatology and has not been approved for use in the treatment of acne vulgaris. Overall, the potential side effects of tetracycline are similar to those of other antibiotics, but there are no proven or proven treatment options available to reduce the risk of adverse reactions associated with its use. In conclusion, tetracycline is an effective and safe topical treatment option for acne vulgaris. It is important to use tetracycline as directed and to consult with a healthcare professional before starting any new medication.
Tetracycline for Acne Vulgaris (Tetra) cream for oralTetracycline topical solutions have been found to be effective in the treatment of acne vulgaris. The most commonly reported side effects include:
The topical application of tetracycline cream to acne vulgaris requires careful handling and storage to minimize the risk of bacterial contamination and to provide a more comfortable, more comfortable environment. The tetracycline cream may cause discoloration of the skin and may even be more harmful to the skin than the topical solution, making it more likely to become a harmful substance. For acne vulgaris, the topical application of tetracycline cream may not be effective, as it may not be absorbed into the skin. Therefore, it is important to use tetracycline topical solutions correctly to ensure the correct application of the medication.
Tetracycline is an antibiotic that is commonly prescribed for the treatment of acne. Acne vulgaris is a skin condition that can result from the overgrowth of acne-causing bacteria. In the treatment of acne, tetracycline topical solutions can help to restore normal levels of acne-causing bacteria and prevent the development of acne-causing acne lesions. In addition to topical treatments, tetracycline has been found to be effective in the treatment of acne vulgaris. The medication can be applied directly to the affected area using a thin layer of the medication to create a protective barrier that can prevent the growth of bacteria that cause acne-causing bacteria. Tetracycline can also be applied to acne lesions using a gel or cream to reduce the number of lesions and promote new acne-causing bacteria growth. In some cases, tetracycline may be necessary to prevent the development of acne lesions in the long term, which may require ongoing management of acne.
Tetracycline for Acne Vulgaris (Tetra) creamTetracycline has been found to be effective in the treatment of acne vulgaris.
The topical application of tetracycline can be a convenient and effective option to address acne-causing bacteria in the treatment of acne vulgaris. This medication is available in both topical and systemic forms, which is why it is essential to use the right formulation for each patient.
Doxycycline is a antibiotic. Doxycycline works by inhibiting the growth of bacteria and then kills the bacteria.
Doxycycline is a prescription drug that can only be used after consulting a doctor.
Doxycycline can also be used to treat some other infections, including:
Doxycycline can also be used to treat:
Doxycycline can be used to treat many different types of infections. It is usually administered as a pill. It is usually taken orally. Doxycycline can be taken with or without food. Patients should take the infection with a full glass of water only. Do not take more than one dose ofoxycycline at a time. This is a medicine. Make sure you give plenty of water while you are takingoxycycline.
This belongs to a class of medications called antibiotics.
Take Doxycycline by mouth as directed by your doctor, usually on an empty stomach. Swallow the medicine with a full glass of water. You may take Doxycycline on an empty stomach a few times a day, just like you would any other medication. DO NOT take more than the prescribed dose of doxycycline at a time.
The most common side effects of Doxycycline (Neurotetracycline) side effects are diarrhea, nausea, and headache. Patients who experience side effects may usevor information from otherz online doctors that they can provide.
Doxycycline can interact with other medications being taken with Neurotetracycline. Some medications have side effects that are serious enough to include an interaction with Doxycycline. Patients should usevor consulta en ustas de recherche de medications che suby plague dauber.
iya i think
‘Life stopping antibiotics’ are some antibiotics that Doxycycline can be used to treat.
Stade de France Pharmacy